Nicoya – Alto Instrument

  • INDONESIA

    Noor Emma Sophianie, General Manager

    PT DKSH Indonesia
    12930 Jakarta Selatan
    Indonesia

    +62 21 2988 8557

    Email

  • MALAYSIA

    Jasmine Keller, Assistant General Manager, Scientific Instrumentation

    DKSH Technology Sdn. Bhd.
    B-11-01, The Ascent, Paradigm, No. 1, Jalan SS7/26A, Kelana Jaya
    Malaysia

    +60 3-7882 6285

    Email

  • PHILIPPINES

    Camilo Umlas, General Manager

    DKSH Philippines Inc.
    8th Floor Cyber Sigma, Lawton Ave., McKinley West, Fort Bonifacio
    1634 Taguig City
    Philippines

    +63 2 8548 3200

    Email

  • SINGAPORE

    Monica Wan, General Manager

    DKSH Singapore Pte Ltd
    625 Lorong 4 Toa Payoh, #03-00
    319519 Singapore
    Singapore

    +65 6962 3121

    +65 6273 1503

    Email

  • TAIWAN

    Whitney Lin, Manager

    DKSH Taiwan Ltd.
    10th Floor, No.22, Lane 407, Section 2, Tiding Boulevard, Neihu District
    114-93 Taipei
    Taiwan

    +886 2 8752 7935

    Email

  • THAILAND

    Oliver Hammel, Vice President

    DKSH Technology Limited (Head Office)
    2533 Sukhumvit Road, Bangchak, Phrakhanong
    10260 Bangkok
    Thailand

    +66 2 639 7000

    Email

  • VIETNAM

    Nguyen Thi Xuan Mai, Senior Manager, National Sales

    DKSH Technology
    5th Floor, Viettel Complex, 285 Cach Mang Thang Tam Ward 12, District 10/6th
    Floor, Peakview Tower, 36 Hoang Cau O Cho Dua Ward
    70000 Ho Chi Minh City / Dong Da District, Ha Noi
    Vietnam

    +84 28 3812 5806 ext 89604

    +84 8 3812 5807

    Email

  • Alto Brochure


Alto is the world’s first SPR instrument to integrate digital microfluidics (DMF) with nanotechnology-based biosensors.

DMF technology enables all fluidics to be disposable, allowing for precise handling of 2μL sample volumes, crude sample compatibility and zero fluidics maintenance. Alto’s compatibility with automation for both hardware and software provides sample-in/answer-out data, industry leading throughput, and 120 hours of unattended run time.

Every aspect of Alto is designed with user-friendliness and accessibility in mind—from the flexible 16 channel design to the intuitive data analysis platform.

Components

The first‑ever DMF‑powered SPR System

Alto Cartridges have completely revolutionized the interaction of fluidics and SPR sensors by integrating them into one disposable microwell plate.

Applications

  • Kinetics/Affinity Characterization
  • Kinetics/Affinity Screening
  • Competition Assays
  • Yes/No Binding
  • Concentration Analysis
  • Thermodynamics
  • Epitope Mapping/Binning

Compatible With

  • Proteins
  • Antibodies
  • Nucleic Acids
  • Small Molecules
  • Carbohydrates
  • Lipids
  • Cells
  • Viruses
  • Nanoparticles

Powered by the Cloud To Streamline Your Experiments

Alto features an end-to-end software suite that is built directly into the instrument, leverages the power of the cloud, and automates your experiments to reduce hands-on time.

Key Features

Industry-leading Data Quality

  • Minimize noise and dispersion; maximize sensitivity
  • Instantaneous rise times

High-throughput Powered by Automation

  • 16 channels, intelligent assay design/optimization, automated serial dilutions
  • Automation-ready with plate & liquid-handling robots

Sample Friendly

  • Only 2μL required for full kinetics
  • Analyze crude samples with ease

User Friendly

  • Free of high-maintenance fluidic components and obsolete software

What is Digital Microfluidics?

DMF is a liquid-handling technology capable of accurately controlling and manipulating discrete nanoliter-sized droplets through the application of voltage on an array of electrodes.

Why DMF?

DMF fluidic handling technology removes the need for any physical pumps, valves, or tubes and replaces them with a low cost disposable cartridge, providing higher data quality and less hands-on time.

How Does SPR Work With DMF?

We’ve integrated our proprietary localized surface plasmon resonance (LSPR) sensors into DMF cartridges – creating 16 independently addressable channels on a single cartridge.

Advantages of Using DMF-powered SPR

  • Decoupling of flow rate and sensor position from dispersion, increasing data quality
  • Up to 500X less sample volume required— get full kinetics from a 2μL sample volume
  • Decoupling of interaction time from sample volume, increasing assay flexibility
  • Automated serial dilutions—reducing human error and saving time

Meet Alto: The World’s First Digital, High-Throughput, Benchtop SPR System.

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